Optimization of polycaprolactone fibrous scaffold for heart valve tissue engineering

Fabrication and characterization of nanofibrous tricuspid valve scaffold based on polyurethane for heart valve tissue engineering

Objective(s): Tissue engineering represents a new approach to solve the current complications of the heart valve replacements by offering viable valve prosthesis with growth and remodeling capability. In this project, electrospinning and dip coating techniques were used to fabricate heart valve constructs from medical grade polyurethane (PU). Methods: Fir...

Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

A knitted, fibrin-covered polycaprolactone scaffold for tissue engineering of the aortic valve.

State-of-the-art tissue engineered heart valves are not strong enough to withstand aortic blood pressure levels. When a strong and slowly degrading scaffold is used, the starting position of valvular tissue engineering is a stronger valve and seeded cells are allowed more time to create a strong extracellular matrix. A polycaprolactone knitted patch with leaflets was developed as a valvular sca...

Electrospun biocompatible Gelatin-Chitosan/Polycaprolactone/Hydroxyapatite nanocomposite scaffold for bone tissue engineering

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

Fuzzy VIKOR Optimization for Designing High Performance Hydroxyapatite/Polycaprolactone Scaffolds for Hard Tissue Engineering